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Title: The A-Z of Zika drug discovery Author: Mottin, Melina; Perryman, Alexander L.; Andrade, Carolina Horta; Borba, Joyce V.V.B.; Braga, Rodolpho C.; Torres, Pedro H.M.; Martini, Matheus C.; Proenca-modena, Jose Luiz; Judice, Carla C.; Costa, Fabio T.M.; Ekins, Sean Year: 2018 Is part of: DRUG DISCOVERY TODAY, v. S1359, p. 30041-2 - DOI: https://doi.org/10.1016/j.drudis.2018.06.014 Citation: Mottin, Melina; Perryman, Alexander L.; Andrade, Carolina Horta; Borba, Joyce V.V.B.; Braga, Rodolpho C.; Torres, Pedro H.M.; Martini, Matheus C.; Proenca-modena, Jose Luiz; Judice, Carla C.; Costa, Fabio T.M.; Ekins, Sean; The A-Z of Zika drug discovery. DRUG DISCOVERY TODAY, v.S1359, p. 30041-2-, 2018 Abstract: Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A-Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond. Funding: This work was partially supported by the Brazilian CNPq/FAPEG DCR Grant 300508/2017-4 and by the Sao Paulo Research Foundation (FAPESP) Grants 16/00194-8, 2017/02353-9, 2016/13805-5, 2012/16525-2. C.H.A. thanks the FAPESP Visiting Researcher Program (grant 2017/02353-9). F.T.M.C. and C.H.A. have CNPq productivity fellowships. C.H.A. also thanks the L'Oreal-UNESCO-ABC Para Mulheres na Ciencia and L'Oreal-UNESCO International Rising Talents Program for the awards and fellowships received. We sincerely thank the OpenZika project (http://openzika.ufg.br), the wonderful ongoing support and encouragement of the IBM's World Community Grid team and the community of volunteers who donate their computer time. |
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