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Title: The role of lipids in the inception, maintenance and complications of dengue virus infection Author: Prates, Mirela C. M.; Carenzi, Lucas R.; Demarco, Ricardo C.; Massuda, Eduardo T.; Aragon, Davi; Valera, Fabiana C. P.; Arruda, Eurico; Anselmo-lima, Wilma T.; Tamashiro, Edwin; Proenca-modena, José L.; Criado, Miriã F.; Saturno, Tamara H.; Oliveira, Anibal S.; Buzatto, Guilherme P.; Jesus, Bruna L. S.; Jacob, Marcos G. Year: 2018 Is part of: Canadian Journal of Infectious Diseases & Medical Microbiology, v. 2018, p. 1 - 9 DOI: https://doi.org/10.1155/2018/5406467 Citation: Prates, Mirela C. M.; Carenzi, Lucas R.; Demarco, Ricardo C.; Massuda, Eduardo T.; Aragon, Davi; Valera, Fabiana C. P.; Arruda, Eurico; Anselmo-lima, Wilma T.; Tamashiro, Edwin; Proenca-modena, José L.; Criado, Miriã F.; Saturno, Tamara H.; Oliveira, Anibal S.; Buzatto, Guilherme P.; Jesus, Bruna L. S.; Jacob, Marcos G.; The role of lipids in the inception, maintenance and complications of dengue virus infection. Canadian Journal of Infectious Diseases & Medical Microbiology, v.2018, p. 1-9, 2018 Abstract: Dengue fever is a viral condition that has become a recurrent issue for public health in tropical countries, common endemic areas. Although viral structure and composition have been widely studied, the infection phenotype in terms of small molecules remains poorly established. This contribution providing a comprehensive overview of the metabolic implications of the virus-host interaction using a lipidomic-based approach through direct-infusion high-resolution mass spectrometry. Our results provide further evidence that lipids are part of both the immune response upon Dengue virus infection and viral infection maintenance mechanism in the organism. Furthermore, the species described herein provide evidence that such lipids may be part of the mechanism that leads to blood-related complications such as hemorrhagic fever, the severe form of the disease. Funding: CFORM would like to thank the Sao Paulo Research Foundation by the grant (16/17066-2). We also thank the Coordination for the Improvement of Higher Level Personnel (CAPES) for the fellowships from TMG (PROEX: 1489740) and MZD. DNO would like to thank the Brazilian Ministry of Health (Plano Nacional de Enfrentamento ao Aedes aegypti e a Microcefalia [Brazilian Plan for Fighting Aedes aegypti and Microcephaly]) for the fellowship under process No. 88887.137889/2017-00. JLPM and RRC thank MCTIC-CNPq/MEC-CAPES/MS-Decit/FNDCT No. 14/2016 for the grant. MLN would like to thank the Sao Paulo Research Foundation for the grant (FAPESP, Process No. 13/21719-3). Finally, RRC would like to thank the Sao Paulo Research Foundation for the grant (FAPESP, Process Nos. 11/50400-0 and 15/06809-1). |
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