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Title: Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway Author: Amaral, Maria E.; Franchini, Kleber G.; Velloso, Licio A.; Barbuio, Raquel; Milanski, Marciane; Romanatto, Talita; Barbosa, Helena C.; Nadruz, Wilson; Bertolo, Manoel B.; Boschero, Antonio C.; Saad, Mario J. A. Year: 2006 Is part of: Journal of Neurochemistry, v. 98, p. 203 - 212 DOI: https://doi.org/10.1111/j.1471-4159.2006.03857.x Citation: Amaral, Maria E.; Franchini, Kleber G.; Velloso, Licio A.; Barbuio, Raquel; Milanski, Marciane; Romanatto, Talita; Barbosa, Helena C.; Nadruz, Wilson; Bertolo, Manoel B.; Boschero, Antonio C.; Saad, Mario J. A.; Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway. Journal of Neurochemistry, v.98, p. 203-212, 2006 Abstract: Aims: Hypothalamic obesity is a severe condition without any effective therapy. Bariatric operations appear as an alternative treatment, but the effects of this procedure are controversial. We, herein, investigated the effects of duodeno-jejunal bypass (DJB) surgery upon the lipid profile and expression of genes and proteins, involved in the regulation of hepatic lipid metabolism, in hypothalamic obese (IIyO) rats. Funding: This study was supported by grants from Fundacao Araucaria (155/2013 and 393/2013), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (817693/2015) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (2015/12611-0). |
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