Article

Download article 		Title: ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice
Author: Ferreira, Sandra Mara; Barbosa-sampaio, Helena Cristina; Santos, Gustavo Jorge; Rezende, Luiz F.; Gonçalves, Luciana Mateus; Santos-silva, Junia Carolina; Bigarella, Carolina Louzão; Carneiro, Everardo Magalhães; Saad, Sara Teresinha Ollala; Boschero, Antonio Carlos
Year: 2015
Is part of: Life Sciences (1973), v. 3205, p. 113-7 -
DOI: https://doi.org/10.1016/j.lfs.2015.01.041

Citation: Ferreira, Sandra Mara; Barbosa-sampaio, Helena Cristina; Santos, Gustavo Jorge; Rezende, Luiz F.; Gonçalves, Luciana Mateus; Santos-silva, Junia Carolina; Bigarella, Carolina Louzão; Carneiro, Everardo Magalhães; Saad, Sara Teresinha Ollala; Boschero, Antonio Carlos; ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice. Life Sciences (1973), v.3205, p. 113-7-, 2015

Abstract: Aims: ARHGAP21 is a Rho GTPase-activating protein (RhoGAP) that associates with many proteins and modulates several cellular functions, including actin cytoskeleton rearrangement in different tissues. However, it is unknown whether ARHGAP21 is expressed in pancreatic beta cells and its function in these cells. Herein, we assess the participation of ARHGAP21 in insulin secretion.



Funding: We thank F. Ortis (Department of Biology and Cellular Development, Institute of Biomedical Sciences, State University of Sao Paulo) for scientific help, M. Camellossi for technical assistance, (Department of Structural and Functional Biology, Institute of Biology, State University of Campinas), and Dr. Nicola Conran for English revision. This work was supported by the following Brazilian foundations: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP 2011/12050-7), Conselho Nacional de Pesquisa (CNPq 472028/2010-3) and Instituto Nacional de Obesidade e Diabetes (INOD 08/57952-5). 		Financed by: