Title: Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains
Author: Ribeiro, Lígia Nunes De Morais; Fonseca, Belchiolina Beatriz; De Paula, Eneida; Rossi, Daise Aparecida; Monteiro, Guilherme Paz; Júnior, Edson Campos Valadares; Silva, Rogério Reis; Franco, Rodrigo; Espíndola, Foued Salmen; Goulart, Luiz Ricardo
Is part of: PHARMACEUTICS, v. 12, p. 769 -
Citation: Ribeiro, Lígia Nunes De Morais; Fonseca, Belchiolina Beatriz; De Paula, Eneida; Rossi, Daise Aparecida; Monteiro, Guilherme Paz; Júnior, Edson Campos Valadares; Silva, Rogério Reis; Franco, Rodrigo; Espíndola, Foued Salmen; Goulart, Luiz Ricardo; Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains. PHARMACEUTICS, v.12, p. 769-, 2020
Abstract: This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability for 180 days (4 degrees C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the in vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity against different multidrug-resistant bacterial strains, such asSalmonellasp.,Pseudomonasaeruginosa,E. coliandCampylobacterjejuni, in comparison to commercial NOR and liposomal suspensions. The in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in any of the different parameters analyzed, a result also corroborated by the analyses of biochemical biomarkers of the chicken-embryos liver function.
Keywords: drug delivery systems; hybrid systems; liposomes;
Funding: This research was funded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES-(#88887.336865/2019-00) and National Institute of Science and Technology in Theranostics and Nanobiotechnology -INCT-Teranano (CNPq/CAPES/FAPEMIG, Grant #CNPq-465669/2014-0).