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Title: Tamoxifen Is Effective in the Treatment of Leishmania amazonensis infections in mice Author: Miguel, D. C.; Yokoyama-yasunaka, J. K. U.; Uliana, S. R. B. Year: 2008 Is part of: Plos Neglected Tropical Diseases, v. 2, p. e249 - 253 DOI: https://doi.org/10.1371/journal.pntd.0000249 Citation: Miguel, D. C.; Yokoyama-yasunaka, J. K. U.; Uliana, S. R. B.; Tamoxifen Is Effective in the Treatment of Leishmania amazonensis infections in mice. Plos Neglected Tropical Diseases, v.2, p. e249-253, 2008 Abstract: Background: Chemotherapy is still a critical issue in the management of leishmaniasis. Until recently, pentavalent antimonials, amphotericin B or pentamidine compounded the classical arsenal of treatment. All these drugs are toxic and have to be administered by the parenteral route. Tamoxifen has been used as an antiestrogen in the treatment and prevention of breast cancer for many years. Its safety and pharmacological profiles are well established in humans. We have shown that tamoxifen is active as an antileishmanial compound in vitro, and in this paper we analyzed the efficacy of tamoxifen for the treatment of mice infected with Leishmania amazonensis, an etiological agent of localized cutaneous leishmaniasis and the main cause of diffuse cutaneous leishmaniasis in South America. Funding: This work was funded by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Cientificoe Tecnologico (CNPq). DCM was supported by a FAPESP fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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