Article

Download article 		Title: Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity
Author: Cereda, Cintia Maria Saia; Grillo, Renato; Fraceto, Leonardo; Calafatti, Silvana A.; Tofoli, Giovana; Mecatti, Daniel; Papini, Juliana; Bueno, Diego; Franz-montan, Michelle; Rocha, Thalita; Pedrazzoli Júnior, José; De Paula, Eneida; De Araujo, Daniele Ribeiro
Year: 2018
Is part of: Journal of Pain Research, v. Volume 11, p. 683 - 691
DOI: https://doi.org/10.2147/jpr.s158695

Citation: Cereda, Cintia Maria Saia; Grillo, Renato; Fraceto, Leonardo; Calafatti, Silvana A.; Tofoli, Giovana; Mecatti, Daniel; Papini, Juliana; Bueno, Diego; Franz-montan, Michelle; Rocha, Thalita; Pedrazzoli Júnior, José; De Paula, Eneida; De Araujo, Daniele Ribeiro; Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity. Journal of Pain Research, v.Volume 11, p. 683-691, 2018

Abstract: Objective: This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi (R), a racemic bupivacaine (BVC) containing 25% dextrobupivacaine and 75% levobupivacaine.

Keywords: alginate; bupivacaine; drug delivery; polymers;
Subjects: CIENCIAS_BIOLOGICAS; Farmacologia Bioquímica e Molecular;

Funding: The authors thank Cristalia Produtos Quim Farm Ltda (Sao Paulo, Brazil) for the donation of BVC and FAPESP (2014/14457-5) for the financial support. The authors also thank Mr Edvaldo C Coelho for his contribution in the pharmacokinetics analysis. 		Financed by: