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Title: Bupivacaine (S75:R25) Loaded in Nanostructured Lipid Carriers: Factorial Design, HPLC Quantification Method and Physicochemical Stability Study Author: Da Silva, Gustavo Henrique Rodrigues; De Morais Ribeiro, Ligia Nunes; Guilherme, Viviane Aparecida; De Castro, Simone Ramos; Breitkreitz, Marcia Cristina; De Paula, Eneida Year: 2018 Is part of: Current Drug Delivery, v. 15, p. 388 - 396 DOI: https://doi.org/10.2174/1567201814666170726101113 Citation: Da Silva, Gustavo Henrique Rodrigues; De Morais Ribeiro, Ligia Nunes; Guilherme, Viviane Aparecida; De Castro, Simone Ramos; Breitkreitz, Marcia Cristina; De Paula, Eneida; Bupivacaine (S75:R25) Loaded in Nanostructured Lipid Carriers: Factorial Design, HPLC Quantification Method and Physicochemical Stability Study. Current Drug Delivery, v.15, p. 388-396, 2018 Abstract: Background: Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxicity and to increase the action time of lipophilic drugs. Keywords: bupivacaine; drug delivery; local anesthetics; nanostructed lipid carriers; Subjects: CIENCIAS_BIOLOGICAS; Farmacologia Bioquímica e Molecular; CIENCIAS_BIOLOGICAS; Biofísica; Biofísica de Processos e Sistemas; Funding: The authors thank FAPESP (#14/14457-5 grant), CAPES (G.H.R.S. fellowship), and Cristalia Prod. Quim. Farm. Ltda, for kindly providing Novabupi (R). |
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