Article

Download article 		Title: The effect of two drug delivery systems in ropivacaine cytotoxicity and cytokine release by human keratinocytes and fibroblasts
Author: Ferreira, Luiz Eduardo Nunes; Muniz, Bruno Vilela; Burga-sánchez, Jonny; Volpato, Maria Cristina; De Paula, Eneida; Rosa, Edvaldo Antonio Ribeiro; Groppo, Francisco Carlos
Year: 2017
Is part of: Journal of Pharmacy and Pharmacology, v. 69, p. 161 - 171
DOI: https://doi.org/10.1111/jphp.12680

Citation: Ferreira, Luiz Eduardo Nunes; Muniz, Bruno Vilela; Burga-sánchez, Jonny; Volpato, Maria Cristina; De Paula, Eneida; Rosa, Edvaldo Antonio Ribeiro; Groppo, Francisco Carlos; The effect of two drug delivery systems in ropivacaine cytotoxicity and cytokine release by human keratinocytes and fibroblasts. Journal of Pharmacy and Pharmacology, v.69, p. 161-171, 2017

Abstract: ObjectivesModified drug delivery systems have been developed to improve pharmacological properties of local anaesthetics. However, the inflammatory potential of these formulations was not investigated. This study compared the in-vitro effects of ropivacaine (ropi) in plain, liposomal (MLV) or 2-hydroxypropyl--cyclodextrin (HP--CD) formulations on cell viability, apoptosis and cytokine (IL-1, TNF-, IL-6 and IL-10) release.

Keywords: citotoxicity; drug delivery; local anesthesia; ropivacaine;
Subjects: CIENCIAS_BIOLOGICAS; Farmacologia Bioquímica e Molecular;

Funding: This work was supported by the FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo), grants FAPESP #2011/12666-8 and #2012/07310-2. 		Financed by: