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Title: High-fat diet effects on the prostatic adenocarcinoma model and jaboticaba peel extract intake: protective response in metabolic disorders and liver histopathology
Author: Macedo, Aline Barbosa; Mizobuti, Daniela Sayuri; De Almeida Hermes, Tulio; Mâncio, Rafael Dias; Pertille, Adriana; Kido, Larissa Akemi; Cagnon, Valéria Helena Alves; Minatel, Elaine
Year: 2019
Is part of: PHOTOCHEMISTRY AND PHOTOBIOLOGY, v. 1, p. 1 - 19
DOI: https://doi.org/10.1111/php.13179

Citation: Macedo, Aline Barbosa; Mizobuti, Daniela Sayuri; De Almeida Hermes, Tulio; Mâncio, Rafael Dias; Pertille, Adriana; Kido, Larissa Akemi; Cagnon, Valéria Helena Alves; Minatel, Elaine; High-fat diet effects on the prostatic adenocarcinoma model and jaboticaba peel extract intake: protective response in metabolic disorders and liver histopathology. PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.1, p. 1-19, 2019

Abstract: Prostate cancer (PCa), overweight and obesity are frequent worldwide health problems. Clinical studies have shown that increased high-fat diet (HFD) consumption is associated with higher incidence of PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentration in the peel and exhibit positive effects on metabolic disorders and hepatic lesions. Therefore, the aim of the study herein was to investigate the patented jaboticaba peel extract effects (PJE) on different metabolic parameters and liver histopathology in the transgenic adenocarcinoma of the mouse prostate model, receiving a either normolipid diet or HFD for 8 weeks. The results showed that PJE reduced insulin resistance and glucose intolerance, decreased hepatic lipid accumulation, and inflammatory markers such as PPAR gamma and TNF alpha, respectively. In conclusion, the PJE treatment promoted protective effects in the metabolism of insulin and glucose and liver imbalance caused by HFD intake in the PCa model, suggesting that it may be a good protector against metabolic disorders present in overweight and associated with PCa.



Funding: T This study was financed in part by the Coordination for the Qualification of Higher Level Staff in Brazil (Brazil) Finance Code 001 and FAPESP (Sao Paulo Research Foundation-2018/04579-7).
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