Title: Jaboticaba extract prevents prediabetes and liver steatosis in high-fat-fed aging mice
Author: Lamas, C.A.; Cagnon, V.H.A.; Lenquiste, S.A.; Baseggio, A.M.; Cuquetto-leite, L.; Kido, L.A.; Aguiar, A.C.; Erbelin, M.N.; Collares-buzato, C.B.; Maróstica, M.R.
Is part of: Journal of Functional Foods, v. 47, p. 434 - 446
Citation: Lamas, C.A.; Cagnon, V.H.A.; Lenquiste, S.A.; Baseggio, A.M.; Cuquetto-leite, L.; Kido, L.A.; Aguiar, A.C.; Erbelin, M.N.; Collares-buzato, C.B.; Maróstica, M.R.; Jaboticaba extract prevents prediabetes and liver steatosis in high-fat-fed aging mice. Journal of Functional Foods, v.47, p. 434-446, 2018
Abstract: This study investigated the effects of freeze-dried jaboticaba peel (FJP) and jaboticaba tea (JE) on obesity parameters of diet-induced obese rats. Thirty-six male Wistar rats were distributed into six groups: AIN-93 M feed a normal control diet; HFF (obese control) feed a high-fat and fructose diet; Prevention FJP (P. FJP) and Treatment FJP (T. FJP) feed HFF diet with 2% of FJP powder, for 12 and 6 weeks respectively; Prevention JE (P. JE) and Treatment JE (T. JE) were feed with HFF diet and the water was substituted by JE, for 12 and 6 weeks, respectively. Lipid profile, glucose, adiponectin and leptin were measured. Glucose and insulin tolerance, also pancreatic islet insulin secretion were determined. Liver morphology and fat liver accumulation were evaluated. Results showed that HFF-diet induced weight gain, dyslipidemia, glucose intolerance, insulin resistance and hepatic steatosis. All FJP and JE treatments reduced weight gain, adiposity and improved insulin sensitivity. Twelve weeks supplementation increased HDL-cholesterol and prevented hepatic steatosis. Our results suggest that FJP and JE act as functional foods, being a dietary strategy to prevent or control obesity. FJP and JE 12 weeks supplementation can modulate important parameters of obesity and insulin metabolism, preventing liver steatosis in obese rats.
Funding: This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq 140387/2012-9 and 301108/2016-1).