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Title: Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis Author: Do Monte-neto, Rubens L.; Coelho, A. C.; Raymond, F.; Legare, D.; Corbeil, Jacques; Melo, Maria N.; Frezard, F.; Ouellette, M. Year: 2011 Is part of: Plos Neglected Tropical Diseases, v. 5, p. e1167 - DOI: https://doi.org/10.1371/journal.pntd.0001167 Citation: Do Monte-neto, Rubens L.; Coelho, A. C.; Raymond, F.; Legare, D.; Corbeil, Jacques; Melo, Maria N.; Frezard, F.; Ouellette, M.; Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis. Plos Neglected Tropical Diseases, v.5, p. e1167-, 2011 Abstract: Background: Drug resistance is a major problem in leishmaniasis chemotherapy. RNA expression profiling using DNA microarrays is a suitable approach to study simultaneous events leading to a drug-resistance phenotype. Genomic analysis has been performed primarily with Old World Leishmania species and here we investigate molecular alterations in antimony resistance in the New World species L. amazonensis. Funding: This work was supported by the CAPES-PDEE program, the Brazilian National Council for Research and Development CNPq program and CIHR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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