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Title: Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice Author: Ww, Arrais; Ef, Pinto; Rossi-bergmann, B.; Giorgio, S. Year: 2006 Is part of: Acta Tropica, v. 98, p. 130 - 136 DOI: https://doi.org/10.1016/j.actatropica.2006.03.001 Citation: Ww, Arrais; Ef, Pinto; Rossi-bergmann, B.; Giorgio, S.; Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice. Acta Tropica, v.98, p. 130-136, 2006 Abstract: In this study we determined whether exposing mice to hyperbaric oxygen (HBO) would alter various disease parameters of a susceptible mouse strain infected with Leishmania amazonensis. BALB/c mice exposed to HBO (100% O-2 at a pressure of 2.5 ATA, 1 h before parasite inoculation and subsequently for 20 days) showed significant delay in lesion development and reduction in lesion parasite burdens compared with HBO-unexposed mice. Circulating levels of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF-alpha) were significantly elevated in HBO-exposed as compared to HBO-unexposed mice. Concanavalin A-stimulated lymph nodes cultures from HBO-exposed mice released significantly more IFN-gamma and less interleukin 10 (IL-10) than cultures from HBO-unexposed mice, consistent with a skewed Th1 response. These results demonstrate, for the first time, that HBO can play a pathogen control role during leishmaniasis. Further studies are needed to elucidate whether hyperoxia alone or increased atmospheric pressure alone can exert a similar effect. (c) 2006 Elsevier B.V. All rights reserved. |
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