Title: ARHGAP21 as a master regulator of multiple cellular processes
Author: Rosa, L. R. O.; Soares, G. M.; Silveira Lr; Boschero, A. C; Barbosa-sampaio, Helena Cristina
Is part of: JOURNAL OF CELLULAR PHYSIOLOGY, v. 233, p. 8477 - 8481
Citation: Rosa, L. R. O.; Soares, G. M.; Silveira Lr; Boschero, A. C; Barbosa-sampaio, Helena Cristina; ARHGAP21 as a master regulator of multiple cellular processes. JOURNAL OF CELLULAR PHYSIOLOGY, v.233, p. 8477-8481, 2018
Abstract: The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.
Funding: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Grant/Award Numbers: 2015/12611-0, 2012/14993-9, 2013/07607-8; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Grant/Award Number: 132344/2017-3