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Title: Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor-deficient mice Author: Guizoni, Daniele M.; Dorighello, Gabriel G.; Oliveira, Helena C. F.; Delbin, Maria A.; Krieger, Marta H.; Davel, Ana P. Year: 2016 Is part of: Journal of Translational Medicine, v. 14, p. 213 - DOI: https://doi.org/10.1186/s12967-016-0972-z Citation: Guizoni, Daniele M.; Dorighello, Gabriel G.; Oliveira, Helena C. F.; Delbin, Maria A.; Krieger, Marta H.; Davel, Ana P.; Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor-deficient mice. Journal of Translational Medicine, v.14, p. 213-, 2016 Abstract: Background: Endothelial dysfunction associated with hypercholesterolemia is an early event in atherosclerosis characterized by redox imbalance associated with high superoxide production and reduced nitric oxide (NO) and hydrogen peroxide (H2O2) production. Aerobic exercise training (AET) has been demonstrated to ameliorate atherosclerotic lesions and oxidative stress in advanced atherosclerosis. However, whether AET protects against the early mechanisms of endothelial dysfunction in familial hypercholesterolemia remains unclear. This study investigated the effects of AET on endothelial dysfunction and vascular redox status in the aortas of LDL receptor knockout mice (LDLr-/-), a genetic model of familial hypercholesterolemia. Keywords: endothelial dysfunction; exercise; LDL receptor; nitric oxide; Funding: This work was supported by Grant from Sao Paulo Research Foundation-FAPESP (#10/50323-2) and University of Campinas fund (FAEPX-PAPDIC Program #25810); Ph.D. Scholarship from Coordination for the Improvement of Higher Education Personnel-CAPES (DMG) and Research Fellowship from The Brazilian National Council for Scientific and Technological Development-CNPq (APD and HCFO). |
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