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Title: Apolipoprotein CIII overexpression exacerbates diet-induced obesity due to adipose tissue higher exogenous lipid uptake and retention and lower lipolysis rates
Author: Raposo, Helena F.; Paiva, Adriene A.; Kato, Larissa S.; De Oliveira, Helena C. F.
Year: 2015
Is part of: Nutrition & Metabolism, v. 12, p. 61 -
DOI: https://doi.org/10.1186/s12986-015-0058-6

Citation: Raposo, Helena F.; Paiva, Adriene A.; Kato, Larissa S.; De Oliveira, Helena C. F.; Apolipoprotein CIII overexpression exacerbates diet-induced obesity due to adipose tissue higher exogenous lipid uptake and retention and lower lipolysis rates. Nutrition & Metabolism, v.12, p. 61-, 2015

Abstract: Background: Hypertriglyceridemia is a common type of dyslipidemia found in obesity. However, it is not established whether primary hyperlipidemia can predispose to obesity. Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. We have previously observed an increased adiposity in response to a high fat diet (HFD) in mice overexpressing apoCIII. Here, we examined the potential mechanisms involved in this exacerbated response of apoCIII mice to the HFD.

Keywords: adipose tissue; apolipoprotein CIII; Lipolysis; obesity;
Subjects: CIENCIAS_DA_SAUDE; Saúde Pública; Lípides e Lipoproteínas; CIENCIAS_BIOLOGICAS; Bioquímica; Metabolismo e Bioenergética; CIENCIAS_BIOLOGICAS; Fisiologia; Fisiologia endócrina;


Funding: This work was supported by grants from Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP #2011/50400-0 and #2011/51349-8) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq). Raposo HF and Kato LS were supported by FAPESP fellowships. Paiva AA was supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES).
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