Article

Download article 		Title: Liver proteomic response to hypertriglyceridemia in human-apolipoprotein C-III transgenic mice at cellular and mitochondrial compartment levels
Author: Grégory Ehx; Gerin, S.; Mathy, G.; Franck, F.; Oliveira, Hcf; Vercesi, A. E.; Sluse, F. E.
Year: 2014
Is part of: Lipids in Health and Disease, v. 13, p. 116 -
DOI: https://doi.org/10.1186/1476-511X-13-116

Citation: Grégory Ehx; Gerin, S.; Mathy, G.; Franck, F.; Oliveira, Hcf; Vercesi, A. E.; Sluse, F. E.; Liver proteomic response to hypertriglyceridemia in human-apolipoprotein C-III transgenic mice at cellular and mitochondrial compartment levels. Lipids in Health and Disease, v.13, p. 116-, 2014

Abstract: Background: Hypertriglyceridemia (HTG) is defined as a triglyceride (TG) plasma level exceeding 150 mg/dl and is tightly associated with atherosclerosis, metabolic syndrome, obesity, diabetes and acute pancreatitis. The present study was undertaken to investigate the mitochondrial, sub-mitochondrial and cellular proteomic impact of hypertriglyceridemia in the hepatocytes of hypertriglyceridemic transgenic mice (overexpressing the human apolipoproteinC-III).

Keywords: hypertriglyceridemia; mitochondria; proteome;
Subjects: CIENCIAS_BIOLOGICAS; Fisiologia Geral; Metabolismo de Lípides e Lipoproteínas; CIENCIAS_BIOLOGICAS; Bioquímica; Metabolismo e Bioenergética; CIENCIAS_BIOLOGICAS; Bioquímica; Metabolismo e Bioenergética; Bioenergética Mitocondrial;

Funding: This work was supported by a Fond de la Recherche Fondamentale et Collective grant (FRFC 2.4597.11) and by the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) - grant #2011/50400-0. GE and SG are recipients of FRS-FNRS doctoral fellowships. FF is a Research Director of the FRS-FNRS. We would like to thank Dr. Luciane Alberici for providing us with biological samples and Dr. Pierre Leprince and Prof. Edwin de Pauw for providing us with access to proteomic and mass spectrometry platforms. 		Financed by: