Article

Download article 		Title: Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice
Author: Souza, J.C.; Vanzela, E.C; Ribeiro, R.A.; Rezende, L.F.; De Oliveira, C.A.; Carneiro, E.M.; Oliveira, H.C.F.; Boschero, A.C.
Year: 2013
Is part of: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1831, p. 769 - 775
DOI: https://doi.org/10.1016/j.bbalip.2012.12.013

Citation: Souza, J.C.; Vanzela, E.C; Ribeiro, R.A.; Rezende, L.F.; De Oliveira, C.A.; Carneiro, E.M.; Oliveira, H.C.F.; Boschero, A.C.; Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v.1831, p. 769-775, 2013

Abstract: Aims/hypothesis: Changes in cellular cholesterol level may contribute to beta cell dysfunction. Islets from low density lipoprotein receptor knockout (LDLR-/-) mice have higher cholesterol content and secrete less insulin than wild-type (WT) mice. Here, we investigated the association between cholesterol content, insulin secretion and Ca2+ handling in these islets.

Keywords: Calcium handling; Cholesterol; insulin secretion; LDL receptor knock out mice;
Subjects: CIENCIAS_BIOLOGICAS; Fisiologia Geral; Metabolismo de Lípides e de Carboidratos; CIENCIAS_BIOLOGICAS; Fisiologia; Fisiologia de Órgãos e Sistemas; Fisiologia Endócrina; CIENCIAS_BIOLOGICAS; Bioquímica; Metabolismo e Bioenergética;

Funding: This study was supported by these Brazilian foundations: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes), Conselho Nacional de Pesquisa (CNPq) and Instituto Nacional de Ciencia e Tecnologia de Obesidade e Diabetes. We thank Mr. L. Domingos for the technical assistance. English was edited by the American Journal Experts (certificate AF57-9E6C-3B2D-33C4-C3B5). 		Financed by: