Article

Download article 		Title: Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway
Author: Soares, Gabriela Moreira; Cantelli, Kathia Regina; Balbo, Sandra Lucinei; Ribeiro, Rosane Aparecida; Alegre-maller, Ana Claudia Paiva; Barbosa-sampaio, Helena Cristina; Boschero, Antonio Carlos; Araújo, Allan Cezar Faria; Bonfleur, Maria Lúcia
Year: 2017
Is part of: LIFE SCIENCES, v. 188, p. 68 - 75
DOI: https://doi.org/10.1016/j.lfs.2017.08.035

Citation: Soares, Gabriela Moreira; Cantelli, Kathia Regina; Balbo, Sandra Lucinei; Ribeiro, Rosane Aparecida; Alegre-maller, Ana Claudia Paiva; Barbosa-sampaio, Helena Cristina; Boschero, Antonio Carlos; Araújo, Allan Cezar Faria; Bonfleur, Maria Lúcia; Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway. LIFE SCIENCES, v.188, p. 68-75, 2017

Abstract: Aims: Hypothalamic obesity is a severe condition without any effective therapy. Bariatric operations appear as an alternative treatment, but the effects of this procedure are controversial. We, herein, investigated the effects of duodeno-jejunal bypass (DJB) surgery upon the lipid profile and expression of genes and proteins, involved in the regulation of hepatic lipid metabolism, in hypothalamic obese (IIyO) rats.



Funding: This study was supported by grants from Fundacao Araucaria (155/2013 and 393/2013), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (817693/2015) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (2015/12611-0). 		Financed by: