Helena Coutinho Franco de Oliveira

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Cargo: Professor Colaborador

Pós-doutorado em Biologia Molecular, Columbia University, NY, EUA, 1992-1995

Dep. BIOLOGIA ESTRUTURAL E FUNCIONAL, IB, Unicamp, Campinas, SP

ho98@unicamp.br

Area

  • Biomedical

Research lines

  • Bioenergetics, metabolism and signal transduction

Academic Background

graduation at Ciências Biológicas from Universidade de São Paulo (1985), master's at Physiology from Universidade de São Paulo (1988) and doctorate at Physiology from Universidade de São Paulo (1992). Has experience in Physiology, focusing on Endocrinal Physiology, acting on the following subjects: cetp, mitochondria, oxidative stress, atherosclerosis and hipercolesterolemia.

Research activities

We have focused on the role of plasma lipoprotein metabolism and associated proteins particularly relevant for the development of atherosclerosis, diabetes and obesity. Hormonal, nutritional and pharmacological regulation of key proteins involved in the metabolism of plasma lipoproteins are investigated with the goal of elucidating molecular mechanisms and putative therapeutic targets for cardio-metabolic disturbances. Scientific contributions have been made concerning the understanding of CETP (cholesteryl ester transfer protein) gene expression and its effects regarding atherosclerosis susceptibility and possible new functions of this protein (Oliveira HCF, Raposo HF. Adv Exp Med Biol. 2020). Together with Anibal Vercesi group, we have demonstrated that mitochondrial bioenergetic function and redox state alterations are present in hyperlipidemic states that predispose to atherosclerosis (Oliveira HCF, Vercesi AE.Mol Aspects Med. 2020)

Teaching activities

In undergraduate education, we contribute by participating in disciplines of Physiology and Biophysics, Cell Biology and Biochemistry for undergraduate courses in Medicine, Biology, Nursing, Physical Education, Pharmacy and Speech Therapy. In graduate programs, we contribute with disciplines of Molecular Biology, Lipid Metabolism, Endocrine Pancreas and Metabolism Seminars and Functional and Molecular Biology Seminars.

Extension activities

In addition to Teaching and Research, we develop ad hoc advisory activities for the University itself, Scientific Societies, national and international research funding Agencies, as well as for Scientific Journals. We participate in Examining Boards and Committees inside and outside the University. We organize courses for academic improvement and scientific dissemination. We also work in the administration and management activities within the scope of the Department, Institute and University, as well as in extramural activities linked to the Brazilian Society for Biochemistry and Molecular Biology.

Selected Publications

Oliveira, H.C.F.; Chouinard, R. A.; Agellon, L. B.; Bruce, C.; Ma, L.; Walsh, A.; Breslow, J. L.; Tall, A. R.; Human Cholesteryl Ester Transfer Protein Gene Proximal Promoter Contains Dietary Cholesterol Positive Responsive Elements And Mediates Expression in Small Intestine and Periphery While Predominant Liver and Spleen Expression is Controlled by 5'-distal Sequences. The Journal of Biological Chemistry, v.271, p. 31831-31838, 1996 [ doi:10.1074/jbc.271.50.31831 ]

Oliveira, H.C.F.; Ma, L.; Milne, R.; Marcovina, S.; Inazu, A.; Mabuchi, H.; Tall, A. R.; Cholesteryl Ester Transfer Protein Activity Enhances Plasma Cholesteryl Ester Formation: Studies in CETP Transgenic Mice and Human Genetic CETP Deficiency. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v.17, p. 1045-1052, 1997 [ doi:10.1161/01.atv.17.6.1045 ]

Oliveira, H C F; Cosso, R G; Alberici, L. C.; Maciel, E N; Salerno, A. G.; Dorighello, G. G.; Velho, J A; De Faria E. C.; Vercesi, A. E.; Oxidative stress in atherosclerosis-prone mouse is due to low antioxidant capacity of mitochondria. The FASEB Journal, v.19, p. 278-280, 2005 [ doi:10.1096/fj.04-2095fje ]

Oliveira, Helena C.F.; Vercesi, Anibal E.; Mitochondrial bioenergetics and redox dysfunctions in hypercholesterolemia and atherosclerosis. MOLECULAR ASPECTS OF MEDICINE, v.71, p. 100840-, 2020 [ doi:10.1016/j.mam.2019.100840 ]

Raposo, Helena F.; Forsythe, Patricia; Chausse, Bruno; Castelli, Júlia Z.; Moraes-vieira, Pedro M.; Nunes, Valéria S.; Oliveira, Helena C.F.; Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity.. METABOLISM-CLINICAL AND EXPERIMENTAL, v.114, p. 154429-, 2020 [ doi:10.1016/j.metabol.2020.154429 ]