Personal presentation

Research activities

Researcher fascinated by microbial physiology, characterizing bacterial transport and pathogenicity mechanisms by structural, biochemical and microbiological approaches. Especialist in structural biology by Single Particle Analysis CryoEM. Currently focus on the study of the Tripartite Tricarboxylate Transport family (TTT) in the pathogen Bordetella pertussis. Liked the topic? Come to work with us! Open positions for Masters and PhD students

Teaching activities

Extension activities

Selected Publications

rosa, Leonardo T; Dix, Samuel R; Rafferty, John B; Kelly, David J; Structural basis for high-affinity adipate binding to AdpC (RPA4515), an orphan periplasmic binding protein from the Tripartite Tricarboxylate Transporter (TTT) family in. FEBS Journal, v.-, p. 14304-, 2017 [ doi:10.1111/febs.14304 ]

rosa, Leonardo T.; Bianconi, Matheus E.; Thomas, Gavin H.; Kelly, David J.; Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity. Frontiers in Cellular and Infection Microbiology, v.8, p. 324356-, 2018 [ doi:10.3389/fcimb.2018.00033 ]

rosa, Leonardo T.; Dix, Samuel R.; Rafferty, John B.; Kelly, David J.; A New Mechanism for High-Affinity Uptake of C4-Dicarboxylates in Bacteria Revealed by the Structure of Rhodopseudomonas palustris MatC (RPA3494), a Periplasmic Binding-Protein of the Tripartite Tricarboxylate Transporter (TTT) Family. JOURNAL OF MOLECULAR BIOLOGY, v.1, p. YJMBI 65926-, 2018 [ doi:10.1016/j.jmb.2018.11.016 ]

Jur'nas, Dukas; rosa, Leonardo Talachia; Rey, Martial; Chamot-rooke, Julia; Fronzes, Rémi; Cascales, Eric; Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin. Nature Communications, v.12, p. 6998-, 2021 [ doi:10.1038/s41467-021-27388-0 ]

rosa, Leonardo Talachia; Vernhes, émeline; Soulet, Anne-lise; Polard, Patrice; Fronzes, Rémi; Structural insights into the mechanism of DNA branch migration during homologous recombination in bacteria. The EMBO Journal, v.1, p. online-, 2024 [ doi:10.1038/s44318-024-00264-5 ]