Personal presentation

bachelor's at Farmácia e Bioquímica from Universidade de São Paulo (2005) and doctorate at Physiology from Universidade de São Paulo (2010). , acting on the following subjects: desnutrição, desnutrição protéica, progenitores hematopoéticos, ciclo celular and hemopoese.

Research activities

The aim of our research is to identify the mechanisms by which the gut microbiota contributes to health. In this context, we are particularly interested in bacterial metabolites called short-chain fatty acids (SCFAs, acetate, propionate and butyrate). These molecules are generated by the fermentation of dietary fibers and play an important role in regulating host metabolism and immunity, being recognized as one of the microbiota-host interaction links.

Selected Publications

vinolo, Marco A. R.; Ferguson, G. John; Kulkarni, Suhasini; Damoulakis, George; Anderson, Karen; Bohlooly-y, Mohammad; Stephens, Len; Hawkins, Phillip T.; Curi, Rui; SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor. Plos One, v.6, p. e21205-, 2011 [ doi:10.1371/journal.pone.0021205 ]

vinolo, Marco A.r.; Rodrigues, Hosana G.; Hatanaka, Elaine; Sato, Fábio T.; Sampaio, Sandra C.; Curi, Rui; Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils?. Journal of Nutritional Biochemistry, v., p. ,-, 2010 [ doi:10.1016/j.jnutbio.2010.07.009 ]

Fellows, Rachel; Denizot, Jérémy; Stellato, Claudia; Cuomo, Alessandro; Jain, Payal; Stoyanova, Elena; Balázsi, Szabina; Hajnády, Zoltán; Liebert, Anke; Kazakevych, Juri; Blackburn, Hector; Corrêa, Renan Oliveira; Fachi, José Luís; Sato, Fabio Takeo; Ribeiro, Willian R.; Ferreira, Caroline Marcantonio; Perée, Hélène; Spagnuolo, Mariangela; Mattiuz, Raphaël; vinolo, M. A. R.; Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases. Nature Communications, v.9, p. 105-, 2018 [ doi:10.1038/s41467-017-02651-5 ]

Antunes, Krist Helen; Fachi, José Luís; De Paula, Rosemeire; Da Silva, Emanuelle Fraga; Pral, Laís Passariello; Dos Santos, Adara áurea; Dias, Greicy Brisa Malaquias; Vargas, José Eduardo; Puga, Renato; Mayer, Fabiana Quoos; Maito, Fábio; Zárate-bladés, Carlos R.; Ajami, Nadim J.; Sant?ana, Marcella Ramos; Candreva, Thamiris; Rodrigues, Hosana Gomes; Schmiele, Marcio; Silva Clerici, Maria Teresa Pedrosa; Proença-modena, José Luiz; vinolo, M. A. R.; Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nature Communications, v.10, p. 1-, 2019 [ doi:10.1038/s41467-019-11152-6 ]

Fachi, José Luís; Sécca, Cristiane; Rodrigues, Patrícia Brito; Mato, Felipe Cézar Pinheiro De; Di Luccia, Blanda; Felipe, Jaqueline De Souza; Pral, Laís Passariello; Rungue, Marcella; Rocha, Victor De Melo; Sato, Fabio Takeo; Sampaio, Ulliana; Clerici, Maria Teresa Pedrosa Silva; Rodrigues, Hosana Gomes; Câmara, Niels Olsen Saraiva; Consonni, Sílvio Roberto; Vieira, Angélica Thomaz; Oliveira, Sergio Costa; Mackay, Charles Reay; Layden, Brian T.; vinolo, M. A. R.; Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2. JOURNAL OF EXPERIMENTAL MEDICINE, v.217, p. 2-, 2020 [ doi:10.1084/jem.20190489 ]