Daniel Martins de Souza

Personal photo

Cargo: Professor Doutor II

PhD at Unicamp; Postdoc at the Max Planck Institute and University of Cambridge




  • Biomedical

Research lines

  • Macromolecules Chemistry
  • Neurobiology and behavior

Personal presentation

I am an Associate Professor of Biochemistry and one of the Coordinators of the Biology Area at FAPESP and CNPq. I lead the Laboratory of Neuroproteomics since 2014, when I returned from Germany after a period of 2 years as Principal Investigator at LMU - Ludwig Maximilians Universität Muenchen (12-14). My expertise is mainly in mass spectrometry-based proteomics (shotgun proteomics) and systems biology in silico, employed to clinical and pre-clinical models for psychiatric disorders. I am a Biologist (03), with a PhD in Biochemistry (08) obtained at Unicamp. My postdoctoral experience was at the Max Planck Institute of Psychiatry in Germany (08-10) and at the University of Cambridge in the United Kingdom (10-12), where I also led the Mass Spectrometry Unit at the Cambridge Center for Neuropsychiatric Research (CCNR). At the same time, I was a consultant for Psynova Neurotech Ltd. I was Elected Affiliated Member of the Brazilian Academy of Sciences (17-21) and Affiliated Member of the Academy of Sciences of the State of São Paulo (19-23). I am also a founding member of BrProt and board member of BrMass. I was elected to the board of the Human Proteome Organization (15-17) and I have been a member of the Human Brain Proteome Project Steering Committee since 2015. I am an Associate Editor of npj Schizophrenia (Nature), member of the editorial board of 7 other scientific journals and a permanent editor of a book series entitled "Proteomics, Metabolomics, Interactomics and Systems Biology" by Springer-Nature. I gave more than 60 oral presentations at international conferences, including Plenary Speaker, Keynote Speaker and Chair. H33 (ISI) and H42 (Scholar) with more than 6200 citations (Scholar).

Research activities

Expertise in mass spectrometry-based proteomics (shotgun proteomics) and systems biology in silico, employed to clinical and pre-clinical models for psychiatric disorders.

Teaching activities

Professor of biochemistry and proteomics

Extension activities

Courses on molecular characterization of diseases and mass spectrometry.

Selected Publications

martins-de-souza D; Maccarrone G; Ising, M; Kloiber, S; Lucae, S; Holsboer, F; Turck, Christoph W; Blood mononuclear cell proteome suggests Integrin and Ras signaling as critical pathways for antidepressant treatment response. Biological Psychiatry (1969), v.3223, p. 86-89, 2014 [ doi:10.1016/j.biopsych.2014.01.022 ]

martins-de-souza, Daniel; Guest, Paul C.; Reis-de-oliveira, Guilherme; Schmitt, Andrea; Falkai, Peter; Turck, Christoph W.; An overview of the human brain myelin proteome and differences associated with schizophrenia. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.21, p. 1-32, 2020 [ doi:10.1080/15622975.2020.1789217 ]

Nascimento, Juliana Minardi; Saia-cereda, Verônica M.; Sartore, Rafaela C.; Da Costa, Rodrigo Madeiro; Schitine, Clarissa S.; Freitas, Hercules Rezende; Murgu, Michael; De Melo Reis, Ricardo A.; Rehen, Stevens K.; martins-de-souza, Daniel; Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v.7, p. 1-12, 2019 [ doi:10.3389/fcell.2019.00303 ]