Daniel Martins de Souza

Personal photo

Cargo: Professor Associado I

PhD at Unicamp; Postdoc at the Max Planck Institute (Alemanha) and University of Cambridge (Reino Unido)




  • Biomedical

Research lines

  • Macromolecules Chemistry
  • Neurobiology and behavior

Personal presentation

I am an Associate Professor of Biochemistry and one of the Coordinators of the Biology Area at FAPESP and CNPq. Besides Chair of the Department of Biochemistry, I lead the Laboratory of Neuroproteomics since 2014, when I returned from Germany after a period of 2 years as Principal Investigator at LMU - Ludwig Maximilians Universität Muenchen (12-14). My expertise is mainly in mass spectrometry-based proteomics (shotgun proteomics) and systems biology in silico, employed to clinical and pre-clinical models for psychiatric disorders. I am a Biologist (03), with a PhD in Biochemistry (08) obtained at Unicamp. My postdoctoral experience was at the Max Planck Institute of Psychiatry in Germany (08-10) and at the University of Cambridge in the United Kingdom (10-12), where I also led the Mass Spectrometry Unit at the Cambridge Center for Neuropsychiatric Research (CCNR). At the same time, I was a consultant for Psynova Neurotech Ltd. I was Elected Affiliated Member of the Brazilian Academy of Sciences (17-21) and Affiliated Member of the Academy of Sciences of the State of São Paulo (19-23). I am also a founding member of BrProt and board member of BrMass. I was elected to the board of the Human Proteome Organization (15-17) and I have been a member of the Human Brain Proteome Project Steering Committee since 2015. I am an Associate Editor of npj Schizophrenia (Nature), member of the editorial board of 7 other scientific journals and a permanent editor of a book series entitled "Proteomics, Metabolomics, Interactomics and Systems Biology" by Springer-Nature. I gave more than 60 oral presentations at international conferences, including Plenary Speaker, Keynote Speaker and Chair. H35 (ISI) and H46 (Scholar) with over 8000 citations (Scholar).

Research activities

Expertise in mass spectrometry-based proteomics (shotgun proteomics) and systems biology in silico, employed to clinical and pre-clinical models for psychiatric disorders.

Teaching activities

Professor of biochemistry and proteomics

Extension activities

Courses on molecular characterization of diseases and mass spectrometry.

Selected Publications

martins-de-souza D; Maccarrone G; Ising, M; Kloiber, S; Lucae, S; Holsboer, F; Turck, Christoph W; Blood mononuclear cell proteome suggests Integrin and Ras signaling as critical pathways for antidepressant treatment response. Biological Psychiatry (1969), v.3223, p. 86-89, 2014 [ doi:10.1016/j.biopsych.2014.01.022 ]

Crunfli, Fernanda; Carregari, Victor C.; Veras, Flavio P.; Silva, Lucas S.; Nogueira, Mateus Henrique; Antunes, André Saraiva Leão Marcelo; Vendramini, Pedro Henrique; Valença, Aline Gazzola Fragnani; Brandão-teles, Caroline; Zuccoli, Giuliana Da Silva; Reis-de-oliveira, Guilherme; Silva-costa, Lícia C.; Saia-cereda, Verônica Monteiro; Smith, Bradley J.; Codo, Ana Campos; De Souza, Gabriela F; Muraro, Stéfanie P.; Parise, Pierina Lorencini; Toledo-teixeira, Daniel A.; martins-de-souza D; Morphological, cellular, and molecular basis of brain infection in COVID-19 patients. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.119, p. e2200960119-, 2022 [ doi:10.1073/pnas.2200960119 ]

Nascimento, Juliana Minardi; Saia-cereda, Verônica M.; Zuccoli, Giuliana S.; Reis-de-oliveira, Guilherme; Carregari, Victor Corasolla; Smith, Bradley J.; Rehen, Stevens K.; martins-de-souza D; martins-de-souza, Daniel; Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains. Cell and Bioscience, v.12, p. 1-, 2022 [ doi:10.1186/s13578-022-00928-x ]

Zuccoli, Giuliana S.; Nascimento, Juliana M.; Moraes-vieira, Pedro M.; Rehen, Stevens K.; martins-de-souza D; martins-de-souza, Daniel; Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.273, p. 1-, 2023 [ doi:10.1007/s00406-023-01605-x ]