Marcelo Alves da Silva Mori

Personal photo

Cargo: Professor Doutor I

Livre docência, UNICAMP

Dep. BIOQUÍMICA E BIOLOGIA TECIDUAL, IB, Unicamp, Campinas, SP

morima@unicamp.br

Area

  • Biomedical

Research lines

  • Animal Genetics and Evolution

Personal presentation

Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in a graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Assistant Professor of Biology of Aging in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, serving as the head of department from 2017 through 2021. He was also Research Coordinator of the Institute of Biology in the period of 2018-2020. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Regional secretary of the Brazilian Society for the Progress of Science and Affiliated Member of the Brazilian Academy of Sciences.

Research activities

The main purpose of our lab is to identify and characterize molecular mechanisms involved in the aging process and in response to dietary interventions. We pay particular interest to understand how metabolism contributes to the genesis of age-related diseases like type 2 diabetes, cardiovascular diseases, and neurodegenerative diseases. We focus on the fat tissue - an important site of metabolic integration in multicellular organisms - and ask ourselves how this tissue responds to changes in energy balance and signals to other tissues to inform them about these changes. If not adjusted, this mechanism leads to several chronic diseases, especially in middle aged and elderly individuals. We identified that this control is at least in part exerted by changes in microRNA biogenesis in adipose tissue. When regulated, this process affects animal susceptibility to oxidative stress and influences lifespan.

Teaching activities

Molecular biology, tissue biology and aging biology.

Extension activities

Partnerships with companies, services, consulting and coordination of the UNICAMP\'s task force against COVID-19

Selected Publications

Mori, M. A.; Ferrari, B.; Carayon, P.; Castro, C. H.; Shimuta, S. I.; Luz, J.; Bascand Jl; Araújo, R.C.; Reis Fc; Sgai, D. G.; Fonseca, R. G.; Barros, C. C.; Merino, V. F.; Passadore, M.; Barbosa, A. M.; Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity. Diabetes (New York), v.57, p. 1491-1500, 2008 [ doi:10.2337/db07-1508 ]

Mori, M. A.; Liu, M.; Bezy, O.; Almind, K.; Shapiro, H.; Kasif, S.; Kahn, C. R.; A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease. Diabetes (New York, N.Y.), v.59, p. 2960-2971, 2010 [ doi:10.2337/db10-0367 ]

Mori, Marcelo a.; Kahn, C. ronald; Raghavan, Prashant; Thomou, Thomas; Boucher, Jeremie; Robida-stubbs, Stacey; Macotela, Yazmin; Russell, Steven j.; Kirkland, James l.; Blackwell, T. keith; Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity. Cell Metabolism, v.16, p. 336-347, 2012 [ doi:10.1016/j.cmet.2012.07.017 ]

Mori, Marcelo A.; Cypess, Aaron M.; Kahn, C. Ronald; Thomou, Thomas; Boucher, Jeremie; Lee, Kevin Y.; Lallukka, Susanna; Kim, Jason K.; Torriani, Martin; Yki-järvinen, Hannele; Grinspoon, Steven K.; Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. The Journal of Clinical Investigation, v.124, p. 73468-, 2014 [ doi:10.1172/JCI73468 ]

Thomou, T.; Grinspoon, Steven K.; Gorden, P.; Kahn, C. Ronald; Mori, Marcelo A; Dreyfuss, J. M.; Konishi, M.; Sakaguchi, M.; Wolfrum, C.; Rao, T. N.; Winnay, J. N.; Garcia-martin, R.; Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues. Nature, v.542, p. 450-, 2017 [ doi:10.1038/nature21365 ]